Pathogenesis and management of renal osteodystrophy

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Pathogenesis and treatment of renal osteodystrophy.

Renal osteodystrophy is the term used to describe the many different patterns of the skeletal abnormalities that occur in patients with chronic kidney disease. The main two conditions are osteitis fibrosa, characterized by high bone turnover, increased osteoclastic and osteoblastic activity, and high levels of circulating parathyroid hormone (PTH) and adynamic bone disease characterized by low ...

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Management of renal osteodystrophy in children.

Prevention and treatment of renal osteodystrophy (ROD) are great challenges for pediatric nephrologists. The strategies for prevention and treatment of ROD in children with chronic renal failure (CRF) should be created on an individual basis. The following factors should be considered: age, type of primary disease, rate of progression of CRF, nutrition, acidosis, type of dialysis, and drugs (co...

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Renal osteodystrophy.

The incidence of chronic renal disease is increasing, and the pattern of renal osteodystrophy seems to be shifting from the classic hyperparathyroid presentation to one of low bone turnover. Patients with persistent disease also live longer than previously and are more physically active. Thus, patients may experience trauma as a direct result of increased physical activity in a setting of weake...

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[Renal osteodystrophy and secondary hyperparathyroidism].

High-turnover bone due to excess PTH is one of the main types of renal osteodystrophy. In addition to the classic stimuli of PTH secretion such as hypocalcemia and decreased production of active vitamin D, new mechanisms has been suggested. Furthermore, skeletal resistance to PTH, a classic stimulus of PTH secretion in uremia, has been recently revisited as an underlying abnormality.

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201 - Renal osteodystrophy

2013 whose GFR is reduced due to intrinsic parenchymal damage as opposed to age-related reductions in GFR without another specific intrinsic renal diagnosis. At each level of CKD there may exist a specific form of renal osteodystrophy. The earliest form of renal bone disease (secondary hyperparathyroidism) may be defined by quantitative histomorphometry and/or biochemical profiling (elevated 1-...

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ژورنال

عنوان ژورنال: Indian Journal of Nephrology

سال: 2007

ISSN: 0971-4065

DOI: 10.4103/0971-4065.39168